… in pain transmission in the central nervous system and in neurogenic inflammation in
peripheral tissue. NK 1 receptor antagonists were initially designed for treatment of pain but were …

… An emerging concept in the pain research area is that the immune response associated …
nervous system (CNS) and peripheral nervous system (PNS) may contribute to a variety of pain …

… in immune-related pain. The purpose of this review is to briefly discuss the immune system
involvement in pain … regional pain syndrome, multiple sclerosis, and diabetic neuropathy. The …

… that immune cells have an important role as pain modulators not … several persistent pain
states in which immune cells are … cells release and how these mediators alter pain processing. …

… We assess the clinical evidence for an aberrant immune response contributing to neuropathic
pain and highlight some of the gaps in our knowledge. Finally, we discuss the use of …

… ), but less consistently with immune treatment response. Here, we outline how … immune
system contributes to development and regulation of pain, review specific IgG-mediated pain …

… and peripheral nervous cells, immune cells, and tissues, … pain pathways is still poorly
understood. Thus, in this review we aim to highlight the interplay between pain and immune system…

… of opioids from immune cells. These opioid peptides subsequently activate opioid receptors
on sensory nerves to inhibit pain (for details see “Peripheral analgesic effects of immune cell-…

… Both pain and inflammation can interact with each other in a multi-… immune system and
the related cells in peripheral sensitization and neurogenic inflammation. Various neuro-immune …

… the role of the immune system in pain processing and modulation reveals potential targets
for analgesic drug development and new therapeutic opportunities for managing chronic pain. …